The Relationship between blood pressure parameters and left ventricular output in neonates

Ashraf Kharrat, Daniel Ibarra Rios, Dany E. Weisz, Regan E. Giesinger, Alan Groves, Junmin Yang, Patrick J. McNamara, Prakesh S. Shah, Amish Jain

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow. Study design: This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Analysis was adjusted for relevant covariates. Result: 1060 studies from 485 neonates were included, with a mean GA of 28.4 ± 4.6 weeks and birth weight of 1234 ± 840 grams. LVO was associated positively with SBP and PP, and negatively with GA. PP demonstrated the highest predictive value for identifying infants with LVO < 150 ml/kg/min (area under the curve 0.75 [95% CI 0.68, 0.82]). MBP and DBP demonstrated no correlation with LVO. Conclusion: BP parameters correlate poorly with LVO, irrespective of GA and underlying etiology. Narrow PP may be more reflective of low LVO than low SBP.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalJournal of Perinatology
Issue number5
StatePublished - 1 May 2019


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