TY - JOUR
T1 - The relationship between blood lead, bone lead and child intelligence
AU - Wasserman, Gail A.
AU - Factor-Litvak, Pam
AU - Liu, Xinhua
AU - Todd, Andrew C.
AU - Kline, Jennie K.
AU - Slavkovich, Vesna
AU - Popovac, Dusan
AU - Graziano, Joseph H.
N1 - Funding Information:
We are grateful for the collaboration of our team of Yugoslav pediatricians and psychologists: Sabohete Capuni-Paracka, Suzana Hadzialevic, Vojkan Lekic, Emine Preteni-Redjep, Nada Morina, Aida Musabegovic, and Nait Vrenezi. This work was supported by grants from NIEHS to Dr. Graziano (ES-RO1-03460 and ES-P30-09089) and to Dr. Todd (ES 07384).
PY - 2003/3
Y1 - 2003/3
N2 - We report associations between serial measures of blood lead and intelligence in children age 10-12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with bone lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.
AB - We report associations between serial measures of blood lead and intelligence in children age 10-12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with bone lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.
UR - https://www.scopus.com/pages/publications/0037482127
U2 - 10.1076/chin.9.1.22.14497
DO - 10.1076/chin.9.1.22.14497
M3 - Article
C2 - 12815520
AN - SCOPUS:0037482127
SN - 0929-7049
VL - 9
SP - 22
EP - 34
JO - Child Neuropsychology
JF - Child Neuropsychology
IS - 1
ER -