TY - JOUR
T1 - The regulation of ventilation in diffuse pulmonary fibrosis
AU - Lourenço, Ruy V.
AU - Turino, Gerard M.
AU - Davidson, Lindsay A.G.
AU - Fishman, Alfred P.
N1 - Funding Information:
respiratory Laboratory of the Presbyterian Hospital, New York, New York. This study was supported in part by Research Grants H-2299 and HE-05741 from the National Institutes of Health, Public Health Service, with additional support from the American Heart Association and the New York Heart Association. Manuscript received January 23, 1963. t This work was carried out during the tenure of a fellowship from the John Polachek Foundation for Medical Research. Present address: Department of Medicine, New Jersey College of Medicine and Dentistry, Jersey City, New Jersey. $ Work performed while a Senior Research Fellow of the New York Heart Association. Presently, Investigator of the Health Research Council of the City of New York (Contract No. 1182 and U1138). $ Work performed during the tenure of a Fellowship from the John Polachek Foundation for Medical Research. Present address: Department of Medicine, University College of Rhodesia and Nyasaland, Salisbury, S. Rhodesia.
PY - 1965/2
Y1 - 1965/2
N2 - The present study is concerned with the mechanisms responsible for the high minute ventilation of patients with diffuse pulmonary fibrosis and with the role of the inordinate work of breathing in limiting their ventilatory responses. The basis for the high ventilation was investigated by experimentally modifying the ventilatory stimuli. The role of the excessive work of breathing was assessed by determining the relationship between minute ventilation and work during carbon dioxide breathing. The results indicate that the high minute ventilation of patients with diffuse fibrosis ordinarily arises from an abnormally large number of afferent nervous impulses reaching the respiratory center from the lungs and/or respiratory muscles. In certain patients, i.e., those with low buffering capacities and/or marked hypoxemia, and under certain conditions, i.e., exercise or bronchial obstruction, this heightened ventilation may be increased further by chemical stimulation. The abnormally high work of breathing does not appear to limit the ventilatory responses of the patients with diffuse pulmonary fibrosis.
AB - The present study is concerned with the mechanisms responsible for the high minute ventilation of patients with diffuse pulmonary fibrosis and with the role of the inordinate work of breathing in limiting their ventilatory responses. The basis for the high ventilation was investigated by experimentally modifying the ventilatory stimuli. The role of the excessive work of breathing was assessed by determining the relationship between minute ventilation and work during carbon dioxide breathing. The results indicate that the high minute ventilation of patients with diffuse fibrosis ordinarily arises from an abnormally large number of afferent nervous impulses reaching the respiratory center from the lungs and/or respiratory muscles. In certain patients, i.e., those with low buffering capacities and/or marked hypoxemia, and under certain conditions, i.e., exercise or bronchial obstruction, this heightened ventilation may be increased further by chemical stimulation. The abnormally high work of breathing does not appear to limit the ventilatory responses of the patients with diffuse pulmonary fibrosis.
UR - https://www.scopus.com/pages/publications/0001464304
U2 - 10.1016/0002-9343(65)90174-9
DO - 10.1016/0002-9343(65)90174-9
M3 - Article
C2 - 14256716
AN - SCOPUS:0001464304
SN - 0002-9343
VL - 38
SP - 199
EP - 216
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 2
ER -