The Quest for a Universal Flu Vaccine: Headless HA 2.0

Florian Krammer

doi:10.1016/j.chom.2015.10.003

The Quest for a Universal Flu Vaccine: Headless HA 2.0

Florian Krammer

Research output: Contribution to journal › Short survey › peer-review

48 Scopus citations

Abstract

Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.

Original language	English
Article number	1347
Pages (from-to)	395-397
Number of pages	3
Journal	Cell Host and Microbe
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2015.10.003
State	Published - 14 Oct 2015

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abstract = "Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new {"}headless{"} hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to {"}universal{"} influenza virus vaccines.",

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AB - Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.

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The Quest for a Universal Flu Vaccine: Headless HA 2.0

Abstract

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