THE QUANTITATIVE HISTOCHEMISTRY OF A CHEMICALLY INDUCED EPENDYMOBLASTOMA–II THE EFFECT OF ISCHAEMIA ON SUBSTRATES OF CARBOHYDRATE METABOLISM

Howard S. Maker, Gerard M. Lehrer, Cipora Weiss, Demetra J. Silides, Labe C. Scheinberg

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Abstract

Several metabolic intermediates of glycolysis have been assayed by sensitive, quantitative microtechniques in an experimental mouse ependymoblastoma growing in brain and in cerebral hemispheres of the tumour‐bearing animals after exposure to varying periods of ischaemia prior to freezing. Initial levels of glucose and lactate were higher, and ATP and glucose‐6‐phosphate lower, in the ependymoblastoma than in brain. During ischaemia glucose fell and lactate increased less rapidly in the tumour than in brain. The overall patterns of change in glucose‐6‐phosphate were similar in tumour and brain although the level of glucose‐6‐phosphate was consistently lower in the ependymoblastoma. ATP was very low in the tumour at the time of decapitation and it declined less precipitously than in brain, so that after 2 min of ischaemia levels were similar in the two tissues.

Original languageEnglish
Pages (from-to)1207-1212
Number of pages6
JournalJournal of Neurochemistry
Volume13
Issue number11
DOIs
StatePublished - Nov 1966

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