The pur protein family: Genetic and structural features in development and disease

Edward M. Johnson, Dianne C. Daniel, Jennifer Gordon

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mutations, and disease aberrations. Together with a recent crystal structure of Purα, these data reveal conserved structural features of these proteins that have been adapted to serve functions unique to higher eukaryotes. In humans Pur proteins are critical for myeloid cell development, muscle development, and brain development, including trafficking of mRNA to neuronal dendrites. Pur family members have been implicated in diseases as diverse as cancer, premature aging, and fragile-X mental retardation syndrome. J. Cell. Physiol.

Original languageEnglish
Pages (from-to)930-937
Number of pages8
JournalJournal of Cellular Physiology
Issue number5
StatePublished - May 2013
Externally publishedYes


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