The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene

Jing Li, Laura Simpson, Michelle Takahashi, Christa Miliaresis, Michael P. Myers, Nicholas Tonks, Ramon Parsons

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of cancers. PTEN encodes a phosphatase that recognizes phosphoprotein substrates and the phospholipid, phosphatidylinositol-3,4,5-triphosphate. PTEN inhibited cell growth and/or colony formation in all of the epithelial lines tested with one exception. The decrease in cellular proliferation was associated with an induction of apoptosis and an inhibition of signaling through the phosphatidylinositol 3'-kinase pathway. Akt/protein kinase B, a gene whose antiapoptotic function is regulated by phosphatidylinositol-3,4,5- triphosphate, was able to rescue cells from PTEN-dependent death. PTEN, therefore, appears to suppress tumor growth by regulating phosphatidylinositol 3'-kinase signaling.

Original languageEnglish
Pages (from-to)5667-5672
Number of pages6
JournalCancer Research
Volume58
Issue number24
StatePublished - 15 Dec 1998
Externally publishedYes

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