@article{f25aef6dea254693aef3a24ce879e8b7,
title = "The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders",
abstract = "A collaborative interdisciplinary systems biology framework is proposed to integrate physical and genetic interaction networks data along with genomics to inform insights into the neurobiology of disease that can then be translated to the clinic.",
keywords = "convergence, genetics, interactome, network, neurodevelopmental disorder, pathway, proteomics, psychiatric cell map initiative, psychiatric disorder, psychiatry, systems biology",
author = "Willsey, \{A. Jeremy\} and Morris, \{Montana T.\} and Sheng Wang and Willsey, \{Helen R.\} and Nawei Sun and Nia Teerikorpi and Baum, \{Tierney B.\} and Gerard Cagney and Bender, \{Kevin J.\} and Desai, \{Tejal A.\} and Deepak Srivastava and Davis, \{Graeme W.\} and Jennifer Doudna and Edward Chang and Vikaas Sohal and Lowenstein, \{Daniel H.\} and Hao Li and David Agard and Keiser, \{Michael J.\} and Brian Shoichet and \{von Zastrow\}, Mark and Lennart Mucke and Steven Finkbeiner and Li Gan and Nenad Sestan and Ward, \{Michael E.\} and Ruth Huttenhain and Nowakowski, \{Tomasz J.\} and Bellen, \{Hugo J.\} and Frank, \{Loren M.\} and Khokha, \{Mustafa K.\} and Lifton, \{Richard P.\} and Martin Kampmann and Trey Ideker and State, \{Matthew W.\} and Krogan, \{Nevan J.\}",
note = "Funding Information: We thank all of the PCMI investigators as well as the members of the Willsey, Ideker, State, and Krogan labs for their detailed input and support; Sarah Pyle for graphic design; and Jacqueline Fabius and Alexa Rocourt for their help with Figure 1. Finally, we thank all of the patients and their family members who have made this research possible by donating their time and biomaterials. This work was supported directly or indirectly by NIH/NIMH (U01 MH105575 to M.W.S. and R01 MH110928 and R01 MH109901 to A.J.W. and M.W.S.), NIH/NIGMS (New Innovator Award DP2 GM119139 to M.K.), NIH/NICHD/NHLBI (R01HD081379 to M.K.K.), Edward Mallinckrodt, Jr. Foundation (M.K.K. is a Mallinckrodt Scholar), the QBI at UCSF (Bold \& Basic grant to A.J.W., B.S., and M.v.Z.), the UCSF Weill Institute for Neurosciences (Trailblazer 2017 Award to A.J.W.); the Taube/Koret Center (to S.F.), the Paul G. Allen Family Foundation (Distinguished Investigator Award to M.J.K.), the Human Frontiers in Science Program (postdoctoral fellowship to R.H.), the Intramural Research Program of the NIH, NINDS (to M.E.W.), the Overlook International Foundation (to M.W.S. and A.J.W.), the Department of Psychiatry at UCSF and the UCSF Chancellor's Fund for Precision Medicine (seed funding for the PCMI to A.J.W., M.W.S., and N.J.K.). Funding Information: We thank all of the PCMI investigators as well as the members of the Willsey, Ideker, State, and Krogan labs for their detailed input and support; Sarah Pyle for graphic design; and Jacqueline Fabius and Alexa Rocourt for their help with Figure 1 . Finally, we thank all of the patients and their family members who have made this research possible by donating their time and biomaterials. This work was supported directly or indirectly by NIH/NIMH ( U01 MH105575 to M.W.S. and R01 MH110928 and R01 MH109901 to A.J.W. and M.W.S.), NIH/NIGMS (New Innovator Award DP2 GM119139 to M.K.), NIH/NICHD/NHLBI ( R01HD081379 to M.K.K.), Edward Mallinckrodt, Jr. Foundation (M.K.K. is a Mallinckrodt Scholar), the QBI at UCSF (Bold \& Basic grant to A.J.W., B.S., and M.v.Z.), the UCSF Weill Institute for Neurosciences (Trailblazer 2017 Award to A.J.W.); the Taube/Koret Center (to S.F.), the Paul G. Allen Family Foundation (Distinguished Investigator Award to M.J.K.), the Human Frontiers in Science Program (postdoctoral fellowship to R.H.), the Intramural Research Program of the NIH, NINDS (to M.E.W.), the Overlook International Foundation (to M.W.S. and A.J.W.), the Department of Psychiatry at UCSF and the UCSF Chancellor{\textquoteright}s Fund for Precision Medicine (seed funding for the PCMI to A.J.W., M.W.S., and N.J.K.). ",
year = "2018",
month = jul,
day = "26",
doi = "10.1016/j.cell.2018.06.016",
language = "English",
volume = "174",
pages = "505--520",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "3",
}