The PsychENCODE project

Schahram Akbarian, Chunyu Liu, James A. Knowles, Flora M. Vaccarino, Peggy J. Farnham, Gregory E. Crawford, Andrew E. Jaffe, Dalila Pinto, Stella Dracheva, Daniel H. Geschwind, Jonathan Mill, Angus C. Nairn, Alexej Abyzov, Sirisha Pochareddy, Shyam Prabhakar, Sherman Weissman, Patrick F. Sullivan, Matthew W. State, Zhiping Weng, Mette A. PetersKevin P. White, Mark B. Gerstein, Anahita Amiri, Chris Armoskus, Allison E. Ashley-Koch, Taejeong Bae, Andrea Beckel-Mitchener, Benjamin P. Berman, Gerhard A. Coetzee, Gianfilippo Coppola, Nancy Francoeur, Menachem Fromer, Robert Gao, Kay Grennan, Jennifer Herstein, David H. Kavanagh, Nikolay A. Ivanov, Yan Jiang, Robert R. Kitchen, Alexey Kozlenkov, Marija Kundakovic, Mingfeng Li, Zhen Li, Shuang Liu, Lara M. Mangravite, Eugenio Mattei, Eirene Markenscoff-Papadimitriou, Fábio C.P. Navarro, Nicole North, Larsson Omberg, David Panchision, Neelroop Parikshak, Jeremie Poschmann, Amanda J. Price, Michael Purcaro, Timothy E. Reddy, Panos Roussos, Shannon Schreiner, Soraya Scuderi, Robert Sebra, Mikihito Shibata, Annie W. Shieh, Mario Skarica, Wenjie Sun, Vivek Swarup, Amber Thomas, Junko Tsuji, Harm Van Bakel, Daifeng Wang, Yongjun Wang, Kai Wang, Donna M. Werling, A. Jeremy Willsey, Heather Witt, Hyejung Won, Chloe C.Y. Wong, Gregory A. Wray, Emily Y. Wu, Xuming Xu, Lijing Yao, Geetha Senthil, Thomas Lehner, Pamela Sklar, Nenad Sestan

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297 Scopus citations


Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understanding precisely how these variants contribute to disease will require a deeper appreciation for the mechanisms of gene regulation in the developing and adult human brain. The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type-specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems. We are beginning with a focus on autism spectrum disorder, bipolar disorder and schizophrenia, and expect that this knowledge will apply to a wide variety of psychiatric disorders. This paper outlines the motivation and design of PsychENCODE.

Original languageEnglish
Pages (from-to)1707-1712
Number of pages6
JournalNature Neuroscience
Issue number12
StatePublished - 25 Nov 2015


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