TY - JOUR
T1 - The proposed origin of double minutes from Homogeneously Staining Region (HSR)-marker chromosomes in human neuroblastoma hybrid cell lines
AU - Balaban-Malenbaum, Gloria
AU - Gilbert, Fred
N1 - Funding Information:
The authors thank Lisa Johnson, Asha Rao, and Jan Weisband for their expert technical assistance. This research was supported in part by grants (to F.G.) from the American Cancer Society (CD-11B), and the National Institutes of Health (through the Children's Hospital Cancer Research Center (CA144896, Sub 01)), and the University of Pennsylvania Human Genetics Center (GM20138, Sub 06).
PY - 1980/12
Y1 - 1980/12
N2 - Double minute chromosomes have been reported in a number of human and animal tumors although their origin and function in the cell remain unclear. The fusion of two cell lines without double minutes-a human neuroblastoma line containing another chromosomal abnormality, the homogeneously staining region (HSR), and a mouse fibroblast line-resulted in hybrid clones containing varying numbers of double minutes. The appearance of double minutes occurred coincident with the disappearance of the HSR. We propose that double minutes can originate from the breakdown of an HSR. The possible functional significance of these two chromosome abnormalities is discussed.
AB - Double minute chromosomes have been reported in a number of human and animal tumors although their origin and function in the cell remain unclear. The fusion of two cell lines without double minutes-a human neuroblastoma line containing another chromosomal abnormality, the homogeneously staining region (HSR), and a mouse fibroblast line-resulted in hybrid clones containing varying numbers of double minutes. The appearance of double minutes occurred coincident with the disappearance of the HSR. We propose that double minutes can originate from the breakdown of an HSR. The possible functional significance of these two chromosome abnormalities is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0019251394&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(80)90065-5
DO - 10.1016/0165-4608(80)90065-5
M3 - Article
AN - SCOPUS:0019251394
SN - 0165-4608
VL - 2
SP - 339
EP - 348
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 4
ER -