The prognostic significance of human papilloma virus in sinonasal squamous cell carcinoma

Emily Schlussel Markovic, Kathryn E. Marqueen, Kunal K. Sindhu, Eric J. Lehrer, Jerry Liu, Brett Miles, Eric Genden, Sonam Sharma, Vishal Gupta, William Westra, Alfred Iloreta, Marshall Posner, Krzysztof Misiukiewicz, Richard L. Bakst

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: Human papilloma virus (HPV) has been implicated in the pathology of oropharyngeal head and neck cancers, but its role in sinonasal squamous cell carcinoma (SNSCC) has not been well established. Methods: Thirty-two patients with SNSCC diagnosed between 2011 and 2018 were identified and stratified by HPV status and viral serotype, as determined by PCR. Endpoints including recurrence, metastases and survival were analyzed using the Kaplan-Meier method. Results: Seventeen (53%) patients were HPV-positive and 15 (47%) were HPV-negative. The median follow-up time of living patients was 30.7 months (range 4-123 months). Survival did not differ by HPV status, but HPV+ tumors were more likely to locally recur and metastasize. When stratifying by treatment type, the lowest rate of recurrence occurred in patients receiving surgery and chemoradiation. Conclusion: A significant proportion of sinonasal tumors appear to be associated with HPV. Testing for HPV might be justified in all cases of sinonasal cancers. Further investigation is warranted to better understand the role of HPV in SNSCC.

Original languageEnglish
Pages (from-to)1070-1078
Number of pages9
JournalLaryngoscope investigative otolaryngology
Issue number6
StatePublished - Dec 2020


  • human papilloma virus (HPV)
  • prognosis
  • sinonasal carcinoma


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