The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen

B. J. Classon, A. F. Williams, A. C. Willis, B. Seed, I. Stamenkovic

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Comparison of NH2-terminal protein sequence from the rat OX-44 antigen with the sequence of the human CD37 antigen deduced from a cDNA clone shows that these antigens are species homologues. The CD37 sequence is 244 amino acids in length and lacks a conventional leader sequence. The molecule is likely to have an NH2-terminal cytoplasmic domain followed by three transmembrane sequences that lie within the first 110 amino acids. The rest of the molecule is hydrophillic and contains three sites for N-linked glycosylation.

Original languageEnglish
Pages (from-to)1497-1502
Number of pages6
JournalJournal of Experimental Medicine
Volume169
Issue number4
DOIs
StatePublished - 1989
Externally publishedYes

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