The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless, boss and sina

Marek Mlodzik, Yasushi Hiromi, Corey S. Goodman, Gerald M. Rubin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Studies on the development of the R7 photoreceptor in the Drosophila eye thus far have identified three genes that specifically affect this cell: sevenless, boss and sina. In each of these mutants the R7 precursor develops instead as the equatorial cone cell (EQC). We have isolated an enhancer trap line, H214, in which β-galactosidase is primarily expressed in the R7 cell throughout its development. In mutations of sevenless, boss and sina, expression in H214 is initially reduced although still present in the R7 precursor and persists in the EQC into which it develops. The EQC in wild type never expresses lacZ in H214. This result is in contrast to that seen with other enhancer trap lines that display expression in R7, and indicates that some aspect of R7 differentiation is independent of the genetic pathway(s) involving sevenless, boss and sina.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalMechanisms of Development
Volume37
Issue number1-2
DOIs
StatePublished - Mar 1992
Externally publishedYes

Keywords

  • Drosophila eye
  • H214
  • Positional information
  • bride of sevenless
  • seven in absentia
  • sevenless

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