The Presence of Viral Particles in Hybridoma Clones Secreting Monoclonal Antibodies

Arie H. Bartal, Carl Feit, Robert Erlandson, Yashar Hirshaut

Research output: Contribution to journalLetterpeer-review

31 Scopus citations


To the Editor: Although the development of monoclonal antibodies to human differentiation and tumor-associated antigens is still in its early stages, there is already a growing effort to use such antibodies for clinical purposes, both diagnostic and therapeutic. In a paper in the August 6 issue Cosimi et al. reported on infusing OKT3 monoclonal antibodies into renal-transplant recipients in order to suppress T-cell subsets.* Recent work in our laboratory has raised a substantial question about the safety of the use of mouse monoclonal antibodies in human beings. We have been developing monoclonal antibodies to human connective-tissue differentiation antigens appearing on. . No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)1423
Number of pages1
JournalNew England Journal of Medicine
Issue number23
StatePublished - 10 Jun 1982
Externally publishedYes


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