The practical dietary management of food protein-induced enterocolitis syndrome

Marion Groetch, Mary Grace Baker, Raquel Durban, Rosan Meyer, Carina Venter, Antonella Muraro

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Objective: Food protein-induced enterocolitis syndrome (FPIES) is a non–immunoglobulin E-mediated food allergy with potential risk of malnutrition related to the early onset of disease, frequent avoidance of cow's milk, and the possibility of multiple food triggers. This publication is aimed at providing an evidence-based, practical approach to the dietary management of FPIES. Data Sources: This is a narrative review summarizing information from national and international guidelines, retrospective studies, population studies, review articles, case reports, and case series to evaluate for nutritional risk and develop guidance for risk reduction in children with FPIES. Study Selections: We have included retrospective clinical cohort studies, population-based studies, case reports, and case studies. We did not exclude any studies identified owing to the small number of studies addressing the nutritional management of individuals with FPIES. Results: Children with FPIES are at risk of malnutrition owing to suboptimal oral intake, limited food choices, and knowledge deficits related to feeding. In particular, children with 3 or more FPIES triggers seem to be at increased risk for poor weight gain and developing food aversion. Caregivers of children with FPIES also report a high degree of psychosocial burden. Conclusion: Appropriate dietary management entails the following 3 essential components: supporting normal growth and development, avoidance of allergens, and advancement of complementary foods. Education to avoid the trigger food and assisting caregivers in creating an individualized, well-designed complementary feeding plan to meet the infant's nutritional needs for optimal growth and development are essential management strategies.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalAnnals of Allergy, Asthma and Immunology
Issue number1
StatePublished - Jul 2021


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