The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test

Ann Rotem; Joseph Ben-Sheetrit; Jeffrey Newcorn; Yaron Danieli; Miriam Peskin; Pavel Golubchik; Rachel Ben-Hayun; Abraham Weizman; Iris Manor

doi:10.1177/1087054719897819

The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test

Ann Rotem
, Joseph Ben-Sheetrit
, Jeffrey Newcorn
, Yaron Danieli
, Miriam Peskin
, Pavel Golubchik
, Rachel Ben-Hayun
, Abraham Weizman
, Iris Manor

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners’ Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p =.032), which was age-dependent (b =.0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.

Original language	English
Pages (from-to)	1311-1320
Number of pages	10
Journal	Journal of Attention Disorders
Volume	25
Issue number	9
DOIs	https://doi.org/10.1177/1087054719897819
State	Published - Jul 2021

Keywords

adult ADHD
continuous performance test
placebo response

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title = "The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test",

abstract = "Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners{\textquoteright} Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p =.032), which was age-dependent (b =.0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.",

keywords = "adult ADHD, continuous performance test, placebo response",

author = "Ann Rotem and Joseph Ben-Sheetrit and Jeffrey Newcorn and Yaron Danieli and Miriam Peskin and Pavel Golubchik and Rachel Ben-Hayun and Abraham Weizman and Iris Manor",

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year = "2021",

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doi = "10.1177/1087054719897819",

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T1 - The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test

AU - Rotem, Ann

AU - Ben-Sheetrit, Joseph

AU - Newcorn, Jeffrey

AU - Danieli, Yaron

AU - Peskin, Miriam

AU - Golubchik, Pavel

AU - Ben-Hayun, Rachel

AU - Weizman, Abraham

AU - Manor, Iris

N1 - Publisher Copyright: © The Author(s) 2020.

PY - 2021/7

Y1 - 2021/7

N2 - Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners’ Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p =.032), which was age-dependent (b =.0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.

AB - Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners’ Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p =.032), which was age-dependent (b =.0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.

KW - adult ADHD

KW - continuous performance test

KW - placebo response

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DO - 10.1177/1087054719897819

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EP - 1320

JO - Journal of Attention Disorders

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IS - 9

ER -

The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test

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