Abstract
This chapter discusses the interaction of each pituitary hormone with bone and the potential it holds in understanding and treating osteoporosis. The discovery of glycoprotein hormones and their direct regulation of bone help explain some of the inconsistencies of older models that assumed that pituitary signaling was mediated entirely via endocrine organs through steroid-family signals. Important direct responses include actions of growth hormone (GH), thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), adrenocorticotrophic hormone (ACTH), and oxytocin (OT) in bone. It is important, in evaluating these new signaling mechanisms, to consider that the skeletal responses may or may not have similar mechanisms to the responses of the traditional endocrine targets, and that the signals may vary in importance due to secondary endocrine and paracrine control. The discovery of direct skeletal responses of pituitary hormones nevertheless offers a new set of therapeutic opportunities.
Original language | English |
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Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism |
Subtitle of host publication | Eighth Edition |
Publisher | Wiley-Blackwell |
Pages | 969-977 |
Number of pages | 9 |
ISBN (Electronic) | 9781118453926 |
ISBN (Print) | 9781118453889 |
DOIs | |
State | Published - 19 Jul 2013 |
Keywords
- Adrenocorticotrophic hormone (ACTH)
- Bone loss
- Follicle stimulating hormone (FSH)
- Growth hormone (GH)
- Oxytocin (OT)
- Pituitary hormone
- Thyroid stimulating hormone (TSH)