The pituitary-bone axis in health and disease

Mone Zaidi, Tony Yuen, Wahid Abu-Amer, Peng Liu, Terry F. Davies, Maria I. New, Harry C. Blair, Alberta Zallone, Clifford J. Rosen, Li Sun

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The skeletal expression of pituitary glycoprotein receptors reflects that their function in endocrine control is evolutionarily more recent. Thus, growth hormone (GH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin (PRL), oxytocin (OXT), and vasopressin (AVP) all affect bone and, in mice, the haploin sufficiency of either the ligand and/or receptor often yields a skeletal phenotype with the primary target organ remaining unperturbed. Recognition and in-depth analysis of the mechanism of action of each pituitary hormone has improved the understanding of bone pathophysiology and opens new avenues for therapy. This chapter discusses the interaction of each pituitary hormone with bone and the potential it holds in understanding and treating osteoporosis. The presence of G-protein coupled receptors (GPCRs) in tissues other than traditional endocrine targets, such as the skeleton, and in some cases, coexistence of their ligands, comes as no surprise.

Original languageEnglish
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Number of pages10
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
StatePublished - 1 Jan 2018


  • Adrenocorticotrophic hormone
  • Endocrine control
  • Follicle-stimulating hormone
  • G-protein coupled receptors
  • Glycoprotein receptors
  • Growth hormone
  • Oxytocin
  • Pituitary hormone
  • Prolactin
  • Thyroid-stimulating hormone


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