TY - CHAP
T1 - The pituitary-bone axis
AU - Zaidi, Mone
AU - Sun, Li
AU - Iqbal, Jameel
N1 - Funding Information:
M.Z. and L.S. are supported by grants from the National Institutes of Health. J.I. acknowledges the support of the American Federation for Aging Research.
PY - 2011
Y1 - 2011
N2 - Osteoporosis is a crippling disease, marked by skeletal fragility and resulting in a fracture in one out of every two individuals over the age of 50. What causes this increased bone fragility and resulting susceptibility fractures has, however, remained unclear. In the early 1700s the British surgeon John Hunter hypothesized that bone undergoes remodeling, that is, bone is forever changing itself by reorganizing into a newer, stronger configuration to resist ongoing stresses, such as physical activity [1]. Bone is lost when the cells degrading old bone, the osteoclasts, outpace the cells re-laying new collagen and mineral, the osteoblasts.
AB - Osteoporosis is a crippling disease, marked by skeletal fragility and resulting in a fracture in one out of every two individuals over the age of 50. What causes this increased bone fragility and resulting susceptibility fractures has, however, remained unclear. In the early 1700s the British surgeon John Hunter hypothesized that bone undergoes remodeling, that is, bone is forever changing itself by reorganizing into a newer, stronger configuration to resist ongoing stresses, such as physical activity [1]. Bone is lost when the cells degrading old bone, the osteoclasts, outpace the cells re-laying new collagen and mineral, the osteoblasts.
UR - http://www.scopus.com/inward/record.url?scp=79960709802&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-8002-1_26
DO - 10.1007/978-1-4419-8002-1_26
M3 - Chapter
C2 - 21691968
AN - SCOPUS:79960709802
SN - 9781441980014
T3 - Advances in Experimental Medicine and Biology
SP - 119
EP - 123
BT - Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology
A2 - New, Maria
A2 - Simpson, Joe Leigh
ER -