TY - JOUR
T1 - The peroxisomes strike BAK
T2 - Regulation of peroxisome integrity by the Bcl-2 family
AU - Chipuk, Jerry Edward
AU - Luna-Vargas, Mark P.A.
N1 - Publisher Copyright:
© 2017 Chipuk and Luna-Vargas.
PY - 2017/3/6
Y1 - 2017/3/6
N2 - Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.
AB - Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.
UR - http://www.scopus.com/inward/record.url?scp=85021848548&partnerID=8YFLogxK
U2 - 10.1083/jcb.201701187
DO - 10.1083/jcb.201701187
M3 - Article
C2 - 28193702
AN - SCOPUS:85021848548
SN - 0021-9525
VL - 216
SP - 547
EP - 549
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 3
ER -