The Pattern Electroretinogram in Optic Nerve Disease

William Seiple; Michael J. Price; Mark Kupersmith; Irwin M. Siegel; Ronald E. Carr

doi:10.1016/S0161-6420(83)80057-8

The Pattern Electroretinogram in Optic Nerve Disease

William Seiple, Michael J. Price, Mark Kupersmith, Irwin M. Siegel, Ronald E. Carr

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34 Scopus citations

Abstract

Pattern evoked electroretinograms (PERG), diffuse flash electroretinograms (ERG) and visual evoked potentials were studied in patients with unilateral optic nerve disease. Patients with Snellen acuities of less than 6/30 did not have recordable PERGs in their affected eye, whereas their diffuse flash ERGs were normal. The VEPs were correspondingly reduced or absent when recorded from the poorer seeing eyes. A second group of patients with Snellen acuity between 6/6 and 6/30 in the involved eye showed reductions in the mean PERG amplitude of the affected as compared with the normal eyes. All affected eyes showed an abnormal contrast threshold measured with the PERG amplitude. Such results underscore the diagnostic value of the PERG in detecting even mildly affected cases of optic nerve disease.

Original language	English
Pages (from-to)	1127-1132
Number of pages	6
Journal	Ophthalmology
Volume	90
Issue number	9
DOIs	https://doi.org/10.1016/S0161-6420(83)80057-8
State	Published - 1983
Externally published	Yes

Keywords

flash electroretinogram
meningioma
optic neuritis
pattern electroretinogram
visual evoked potential

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10.1016/S0161-6420(83)80057-8

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@article{669e9afe6ea3400185c6ade90b0545d3,

title = "The Pattern Electroretinogram in Optic Nerve Disease",

abstract = "Pattern evoked electroretinograms (PERG), diffuse flash electroretinograms (ERG) and visual evoked potentials were studied in patients with unilateral optic nerve disease. Patients with Snellen acuities of less than 6/30 did not have recordable PERGs in their affected eye, whereas their diffuse flash ERGs were normal. The VEPs were correspondingly reduced or absent when recorded from the poorer seeing eyes. A second group of patients with Snellen acuity between 6/6 and 6/30 in the involved eye showed reductions in the mean PERG amplitude of the affected as compared with the normal eyes. All affected eyes showed an abnormal contrast threshold measured with the PERG amplitude. Such results underscore the diagnostic value of the PERG in detecting even mildly affected cases of optic nerve disease.",

keywords = "flash electroretinogram, meningioma, optic neuritis, pattern electroretinogram, visual evoked potential",

author = "William Seiple and Price, {Michael J.} and Mark Kupersmith and Siegel, {Irwin M.} and Carr, {Ronald E.}",

note = "Funding Information: Supported in part by Grants #03317 and #02179 from the National Eye Institute, an unrestricted grant to the Department of Ophthalmology from the Research to Prevent Blindness, Inc., The Retinitis Pigmentosa Foundation and a grant from the E. A. Baker Foundation (Dr. Price).",

year = "1983",

doi = "10.1016/S0161-6420(83)80057-8",

language = "English",

volume = "90",

pages = "1127--1132",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "9",

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TY - JOUR

T1 - The Pattern Electroretinogram in Optic Nerve Disease

AU - Seiple, William

AU - Price, Michael J.

AU - Kupersmith, Mark

AU - Siegel, Irwin M.

AU - Carr, Ronald E.

N1 - Funding Information: Supported in part by Grants #03317 and #02179 from the National Eye Institute, an unrestricted grant to the Department of Ophthalmology from the Research to Prevent Blindness, Inc., The Retinitis Pigmentosa Foundation and a grant from the E. A. Baker Foundation (Dr. Price).

PY - 1983

Y1 - 1983

N2 - Pattern evoked electroretinograms (PERG), diffuse flash electroretinograms (ERG) and visual evoked potentials were studied in patients with unilateral optic nerve disease. Patients with Snellen acuities of less than 6/30 did not have recordable PERGs in their affected eye, whereas their diffuse flash ERGs were normal. The VEPs were correspondingly reduced or absent when recorded from the poorer seeing eyes. A second group of patients with Snellen acuity between 6/6 and 6/30 in the involved eye showed reductions in the mean PERG amplitude of the affected as compared with the normal eyes. All affected eyes showed an abnormal contrast threshold measured with the PERG amplitude. Such results underscore the diagnostic value of the PERG in detecting even mildly affected cases of optic nerve disease.

AB - Pattern evoked electroretinograms (PERG), diffuse flash electroretinograms (ERG) and visual evoked potentials were studied in patients with unilateral optic nerve disease. Patients with Snellen acuities of less than 6/30 did not have recordable PERGs in their affected eye, whereas their diffuse flash ERGs were normal. The VEPs were correspondingly reduced or absent when recorded from the poorer seeing eyes. A second group of patients with Snellen acuity between 6/6 and 6/30 in the involved eye showed reductions in the mean PERG amplitude of the affected as compared with the normal eyes. All affected eyes showed an abnormal contrast threshold measured with the PERG amplitude. Such results underscore the diagnostic value of the PERG in detecting even mildly affected cases of optic nerve disease.

KW - flash electroretinogram

KW - meningioma

KW - optic neuritis

KW - pattern electroretinogram

KW - visual evoked potential

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U2 - 10.1016/S0161-6420(83)80057-8

DO - 10.1016/S0161-6420(83)80057-8

M3 - Article

AN - SCOPUS:0020602838

SN - 0161-6420

VL - 90

SP - 1127

EP - 1132

JO - Ophthalmology

JF - Ophthalmology

IS - 9

ER -

The Pattern Electroretinogram in Optic Nerve Disease

Abstract

Keywords

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