The pathology of the feline model of mucopolysaccharidosis I

M. E. Haskins, G. D. Aguirre, P. F. Jezyk, R. J. Desnick, D. F. Patterson

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Five cats with feline α-L-iduronidase-deficient mucopolysaccharidosis were studied. Membrane-bound cytoplasmic inclusions were present in central nervous system neurons, hepatocytes, chondrocytes, vascular and splenic smooth muscle cells, bone marrow leukocytes, and fibroblasts of the skin, eye, and cardiac valves. The lesions in these cats closely resemble those described in human patients with mucopolysaccharidosis I H (Hurler syndrome).

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalAmerican Journal of Pathology
Issue number1
StatePublished - 1983


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