Abstract
Historically, much attention has focused on the mechanisms of activity-dependent plasticity since the description of long-term potentiation by Bliss and Lomo in the early 1970s, while extrasynaptic changes have received much less interest. However, recent work has concentrated on the role of back-propagating action potentials in hippocampal dendrites in synaptic plasticity. In this review, we focus on the modulation of back-propagating action potentials by K+ currents in the dendrites of hippocampal cells. We described the primary K+-channel subunits and their interacting subunits that most likely contribute to these currents, and how these sites can be regulated by phosphorylation and other mechanisms. In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus.
Original language | English |
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Pages (from-to) | 51-66 |
Number of pages | 16 |
Journal | Molecular Neurobiology |
Volume | 25 |
Issue number | 1 |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Extrasynaptic
- Hebbian
- Kv4.2
- LTP
- Learning
- Memory
- Metaplasticity
- Neuromodulation
- Shal
- Suprasynaptic