The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

Lorenzo Sala, Christophe Prud'homme, Giovanna Guidoboni, Marcela Szopos, Alon Harris

Research output: Contribution to journalArticlepeer-review

Abstract

We present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems arising in biomechanics and hemodynamics within the human eye. We discuss our contribution towards improving the reliability and reproducibility of computational studies by performing a thorough validation of the numerical predictions against experimental data. The OMVS proved capable of simulating complex multiphysics and multiscale scenarios motivated by the study of glaucoma. Furthermore, its modular design allows the continuous integration of new models and methods as the research moves forward, and supports the utilization of the OMVS as a promising non-invasive clinical investigation tool for personalized research in ophthalmology.

Original languageEnglish
JournalInternational Journal for Numerical Methods in Biomedical Engineering
DOIs
StateAccepted/In press - 2023
Externally publishedYes

Keywords

  • hybridizable discontinuous Galerkin method
  • mathematical and computational ophthalmology
  • multiphysics and multiscale modeling
  • ocular hemodynamics and biomechanics
  • validation

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