The number of p16INK4a positive cells in human skin reflects biological age

Mariëtte E.C. Waaijer; William E. Parish; Barbara H. Strongitharm; Diana van Heemst; Pieternella E. Slagboom; Anton J.M. de Craen; John M. Sedivy; Rudi G.J. Westendorp; David A. Gunn; Andrea B. Maier

doi:10.1111/j.1474-9726.2012.00837.x

The number of p16INK4a positive cells in human skin reflects biological age

Mariëtte E.C. Waaijer, William E. Parish, Barbara H. Strongitharm, Diana van Heemst, Pieternella E. Slagboom, Anton J.M. de Craen, John M. Sedivy, Rudi G.J. Westendorp, David A. Gunn, Andrea B. Maier

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.

Original language	English
Pages (from-to)	722-725
Number of pages	4
Journal	Aging Cell
Volume	11
Issue number	4
DOIs	https://doi.org/10.1111/j.1474-9726.2012.00837.x
State	Published - Aug 2012
Externally published	Yes

Keywords

Biological age
Cellular senescence
Familial longevity
P16INK4a

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10.1111/j.1474-9726.2012.00837.x

Cite this

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title = "The number of p16INK4a positive cells in human skin reflects biological age",

abstract = "Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.",

keywords = "Biological age, Cellular senescence, Familial longevity, P16INK4a",

author = "Waaijer, {Mari{\"e}tte E.C.} and Parish, {William E.} and Strongitharm, {Barbara H.} and {van Heemst}, Diana and Slagboom, {Pieternella E.} and {de Craen}, {Anton J.M.} and Sedivy, {John M.} and Westendorp, {Rudi G.J.} and Gunn, {David A.} and Maier, {Andrea B.}",

year = "2012",

month = aug,

doi = "10.1111/j.1474-9726.2012.00837.x",

language = "English",

volume = "11",

pages = "722--725",

journal = "Aging Cell",

issn = "1474-9718",

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TY - JOUR

T1 - The number of p16INK4a positive cells in human skin reflects biological age

AU - Waaijer, Mariëtte E.C.

AU - Parish, William E.

AU - Strongitharm, Barbara H.

AU - van Heemst, Diana

AU - Slagboom, Pieternella E.

AU - de Craen, Anton J.M.

AU - Sedivy, John M.

AU - Westendorp, Rudi G.J.

AU - Gunn, David A.

AU - Maier, Andrea B.

PY - 2012/8

Y1 - 2012/8

N2 - Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.

AB - Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.

KW - Biological age

KW - Cellular senescence

KW - Familial longevity

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The number of p16INK4a positive cells in human skin reflects biological age

Abstract

Keywords

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