TY - JOUR
T1 - The N6-Methyladenosine RNA modification in pluripotency and reprogramming
AU - Aguilo, Francesca
AU - Walsh, Martin J.
N1 - Funding Information:
We sincerely apologize to authors whose work could not be included due to space limitations. We thank D. Munoz for graphical design. F.A. is supported by the Knut and Alice Wallenberg Foundation, Umeå University, Västerbotten County Council, and the Cancer Research Foundation in Northern Sweden (LP 16-2126). This work was supported by the Senior Scholar Award in Aging AG-SS-2482-10 and through award 5R01 CA154903 from the NIH.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/10
Y1 - 2017/10
N2 - Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N6-Methyladenosine (m6A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. M6A modification affects a broad spectrum of cellular functions, including maintenance of the pluripotency of embryonic stem cells (ESCs) and the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the most recent findings on m6A modification with special focus on the different studies describing how m6A is implicated in ESC self-renewal, cell fate specification and iPSC generation.
AB - Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N6-Methyladenosine (m6A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. M6A modification affects a broad spectrum of cellular functions, including maintenance of the pluripotency of embryonic stem cells (ESCs) and the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the most recent findings on m6A modification with special focus on the different studies describing how m6A is implicated in ESC self-renewal, cell fate specification and iPSC generation.
UR - http://www.scopus.com/inward/record.url?scp=85021627497&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2017.06.006
DO - 10.1016/j.gde.2017.06.006
M3 - Review article
C2 - 28683341
AN - SCOPUS:85021627497
SN - 0959-437X
VL - 46
SP - 77
EP - 82
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -