TY - JOUR
T1 - The non-Huntington disease choreas
AU - Walker, Ruth H.
N1 - Publisher Copyright:
© 2016 American Academy of Neurology.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose of review: Chorea can be due to a wide variety of causes. In this review, I provide updates on several recently identified genetic and autoimmune causes of chorea, and review evidence supporting the use of deep brain stimulation in chorea. Recent findings: New genes that may cause chorea include ADCY5 (encoding for adenylate cyclase 5) C9ORF72 (in addition to amyotrophic lateral sclerosis and frontotemporal dementia), and those responsible for the neurodegeneration with brain iron accumulation disorders. Novel autoantibodies are increasingly being identified as associated with a variety of neurologic syndromes, including chorea, in both paraneoplastic and non-paraneoplastic settings. Deep brain stimulation can be a useful intervention in patients with chorea who do not respond to oral medications, whether due to neurodegenerative or nondegenerative causes. Summary: New causes of chorea continue to be identified. Correct diagnosis is essential for prognostication and treatment.
AB - Purpose of review: Chorea can be due to a wide variety of causes. In this review, I provide updates on several recently identified genetic and autoimmune causes of chorea, and review evidence supporting the use of deep brain stimulation in chorea. Recent findings: New genes that may cause chorea include ADCY5 (encoding for adenylate cyclase 5) C9ORF72 (in addition to amyotrophic lateral sclerosis and frontotemporal dementia), and those responsible for the neurodegeneration with brain iron accumulation disorders. Novel autoantibodies are increasingly being identified as associated with a variety of neurologic syndromes, including chorea, in both paraneoplastic and non-paraneoplastic settings. Deep brain stimulation can be a useful intervention in patients with chorea who do not respond to oral medications, whether due to neurodegenerative or nondegenerative causes. Summary: New causes of chorea continue to be identified. Correct diagnosis is essential for prognostication and treatment.
UR - https://www.scopus.com/pages/publications/84962745024
U2 - 10.1212/CPJ.0000000000000236
DO - 10.1212/CPJ.0000000000000236
M3 - Review article
AN - SCOPUS:84962745024
SN - 2163-0402
VL - 6
SP - 150
EP - 156
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 2
ER -