The non-Huntington disease choreas

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Purpose of review: Chorea can be due to a wide variety of causes. In this review, I provide updates on several recently identified genetic and autoimmune causes of chorea, and review evidence supporting the use of deep brain stimulation in chorea. Recent findings: New genes that may cause chorea include ADCY5 (encoding for adenylate cyclase 5) C9ORF72 (in addition to amyotrophic lateral sclerosis and frontotemporal dementia), and those responsible for the neurodegeneration with brain iron accumulation disorders. Novel autoantibodies are increasingly being identified as associated with a variety of neurologic syndromes, including chorea, in both paraneoplastic and non-paraneoplastic settings. Deep brain stimulation can be a useful intervention in patients with chorea who do not respond to oral medications, whether due to neurodegenerative or nondegenerative causes. Summary: New causes of chorea continue to be identified. Correct diagnosis is essential for prognostication and treatment.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalNeurology: Clinical Practice
Issue number2
StatePublished - 1 Apr 2016


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