The NKG2D receptor: Immunobiology and clinical implications

Steven J. Burgess; Kerima Maasho; Madhan Masilamani; Sriram Narayanan; Francisco Borrego; John E. Coligan

doi:10.1007/s12026-007-0060-9

The NKG2D receptor: Immunobiology and clinical implications

Steven J. Burgess, Kerima Maasho, Madhan Masilamani, Sriram Narayanan, Francisco Borrego, John E. Coligan

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.

Original language	English
Pages (from-to)	18-34
Number of pages	17
Journal	Immunologic Research
Volume	40
Issue number	1
DOIs	https://doi.org/10.1007/s12026-007-0060-9
State	Published - Jan 2008
Externally published	Yes

Keywords

Activating receptor
DAP10
Natural killer cells
T cells

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AU - Masilamani, Madhan

AU - Narayanan, Sriram

AU - Borrego, Francisco

AU - Coligan, John E.

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AB - NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.

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The NKG2D receptor: Immunobiology and clinical implications

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Keywords

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