The neurosurgeon’s armamentarium for gliomas: An update on intraoperative technologies to improve extent of resection

Alexander J. Schupper; Raymund L. Yong; Constantinos G. Hadjipanayis

doi:10.3390/jcm10020236

The neurosurgeon’s armamentarium for gliomas: An update on intraoperative technologies to improve extent of resection

Alexander J. Schupper, Raymund L. Yong, Constantinos G. Hadjipanayis

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Maximal safe resection is the standard of care in the neurosurgical treatment of high-grade gliomas. To aid surgeons in the operating room, adjuvant techniques and technologies centered around improving intraoperative visualization of tumor tissue have been developed. In this review, we will discuss the most advanced technologies, specifically fluorescence-guided surgery, intraoperative imaging, neuromonitoring modalities, and microscopic imaging techniques. The goal of these technologies is to improve detection of tumor tissue beyond what conventional microsurgery has permitted. We describe the various advances, the current state of the literature that have tested the utility of the different adjuvants in clinical practice, and future directions for improving intraoperative technologies.

Original language	English
Article number	236
Pages (from-to)	1-22
Number of pages	22
Journal	Journal of Clinical Medicine
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/jcm10020236
State	Published - 2 Jan 2021
Externally published	Yes

Keywords

5-ALA
Extent of resection
Fluorescein
Fluorescence-guided surgery
Glioblastoma
Glioma surgery
IMRI
Intraoperative imaging
Neuromonitoring
Ultrasound

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title = "The neurosurgeon{\textquoteright}s armamentarium for gliomas: An update on intraoperative technologies to improve extent of resection",

abstract = "Maximal safe resection is the standard of care in the neurosurgical treatment of high-grade gliomas. To aid surgeons in the operating room, adjuvant techniques and technologies centered around improving intraoperative visualization of tumor tissue have been developed. In this review, we will discuss the most advanced technologies, specifically fluorescence-guided surgery, intraoperative imaging, neuromonitoring modalities, and microscopic imaging techniques. The goal of these technologies is to improve detection of tumor tissue beyond what conventional microsurgery has permitted. We describe the various advances, the current state of the literature that have tested the utility of the different adjuvants in clinical practice, and future directions for improving intraoperative technologies.",

keywords = "5-ALA, Extent of resection, Fluorescein, Fluorescence-guided surgery, Glioblastoma, Glioma surgery, IMRI, Intraoperative imaging, Neuromonitoring, Ultrasound",

author = "Schupper, {Alexander J.} and Yong, {Raymund L.} and Hadjipanayis, {Constantinos G.}",

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AU - Yong, Raymund L.

AU - Hadjipanayis, Constantinos G.

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AB - Maximal safe resection is the standard of care in the neurosurgical treatment of high-grade gliomas. To aid surgeons in the operating room, adjuvant techniques and technologies centered around improving intraoperative visualization of tumor tissue have been developed. In this review, we will discuss the most advanced technologies, specifically fluorescence-guided surgery, intraoperative imaging, neuromonitoring modalities, and microscopic imaging techniques. The goal of these technologies is to improve detection of tumor tissue beyond what conventional microsurgery has permitted. We describe the various advances, the current state of the literature that have tested the utility of the different adjuvants in clinical practice, and future directions for improving intraoperative technologies.

KW - 5-ALA

KW - Extent of resection

KW - Fluorescein

KW - Fluorescence-guided surgery

KW - Glioblastoma

KW - Glioma surgery

KW - IMRI

KW - Intraoperative imaging

KW - Neuromonitoring

KW - Ultrasound

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The neurosurgeon’s armamentarium for gliomas: An update on intraoperative technologies to improve extent of resection

Abstract

Keywords

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