The neurocognitive implications of depression and socioeconomic status in people with HIV

Kaleigh E. Fidaleo, Micah J. Savin, Maral N. Aghvinian, Angela C. Summers, Alyssa Arentoft, Desiree Byrd, Heining Cham, Monica Rivera Mindt

Research output: Contribution to journalArticlepeer-review


Objective: This cross-sectional study investigates the independent and interactive effects of depression and socioeconomic status (SES) on neurocognition in a diverse sample of people with HIV (PWH). Method: The sample of 119 PWH (71% Latinx, 27% female) completed comprehensive neurocognitive and psychosocial evaluations and were separated into two groups: those with a history of depression diagnosis (n = 47) and those without (n = 72). Results: The results of regression analyses indicated that lifetime depression was not associated with lower SES nor with worse neurocognitive performance on any neurocognitive outcome. However, a significant main effect of SES was observed on the Hopkins Verbal Learning Test (total), indicating that higher SES was associated with better verbal learning performance (B= .11, SE = .05, p< .02). Lastly, the results revealed an interactive effect of lifetime depression and SES, such that individuals with depression and higher SES performed better on tests of attention/working memory (i.e., WAIS-III Letter-Number Sequencing, B= .08, SE = .04, p< .02; Paced Auditory Serial Addition Test, B= .39, SE = .16, p< .02). Conclusions: Depression and SES appear to play an important role in the neurocognitive performance of PWH. Specifically, higher SES appears to have a protective effect on attention/working memory among PWH only if they have co-morbid history of lifetime depression.

Original languageEnglish
Pages (from-to)592-603
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Issue number8
StatePublished - 2022


  • HIV
  • Neurocognition
  • depression
  • health disparities
  • socioeconomic status


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