The Neurobiology of Borderline Personality Disorder

Maria Mercedes Perez-Rodriguez, Andrea Bulbena-Cabré, Anahita Bassir Nia, Gillian Zipursky, Marianne Goodman, Antonia S. New

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

Original languageEnglish
Pages (from-to)633-650
Number of pages18
JournalPsychiatric Clinics of North America
Issue number4
StatePublished - Dec 2018


  • Alexithymia
  • Borderline personality disorder
  • Emotion dysregulation
  • Genetics
  • Impulsive aggression
  • Neuroimaging
  • Opioids
  • Oxytocin


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