TY - JOUR
T1 - The Neurobiology of Borderline Personality Disorder
AU - Perez-Rodriguez, Maria Mercedes
AU - Bulbena-Cabré, Andrea
AU - Bassir Nia, Anahita
AU - Zipursky, Gillian
AU - Goodman, Marianne
AU - New, Antonia S.
N1 - Funding Information:
M.M. Perez-Rodriguez has received salary support from NIMH grant KL2TR001435, CDC/NIOSH grant U01 OH011473-01, NIH grant 1R01MH097799-01A1 (PI New), and NARSAD (PI Perez); M.M. Perez-Rodriguez is site-PI (Principal Investigator) of a study funded by Neurocrine Biosciences.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/12
Y1 - 2018/12
N2 - This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.
AB - This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.
KW - Alexithymia
KW - Borderline personality disorder
KW - Emotion dysregulation
KW - Genetics
KW - Impulsive aggression
KW - Neuroimaging
KW - Opioids
KW - Oxytocin
UR - http://www.scopus.com/inward/record.url?scp=85056492663&partnerID=8YFLogxK
U2 - 10.1016/j.psc.2018.07.012
DO - 10.1016/j.psc.2018.07.012
M3 - Review article
C2 - 30447729
AN - SCOPUS:85056492663
VL - 41
SP - 633
EP - 650
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
SN - 0193-953X
IS - 4
ER -