TY - JOUR
T1 - The neural processing of negative emotion postpartum
T2 - A preliminary study of amygdala function in postpartum depression
AU - Silverman, Michael E.
AU - Loudon, Holly
AU - Liu, Xun
AU - Mauro, Casey
AU - Leiter, Gila
AU - Goldstein, Martin A.
PY - 2011/8
Y1 - 2011/8
N2 - While contemporary diagnostic nosology characterizes postpartum depression (PPD) as a specifier of a major depressive disorder (MDD), this classification continues to be questioned. Functional magnetic resonance imaging (fMRI) holds the promise of helping to characterize the neuroanatomical dysfunction associated with dysregulated emotion after childbirth. Twenty postpartum women underwent fMRI in the presence of emotionally valenced stimuli. The observation of relative amygdala non-responsivity in subjects demonstrating greater depression symptomotology stands in contrast to imaging studies of MDD and provides insight into possible phenotypic differences of PPD.
AB - While contemporary diagnostic nosology characterizes postpartum depression (PPD) as a specifier of a major depressive disorder (MDD), this classification continues to be questioned. Functional magnetic resonance imaging (fMRI) holds the promise of helping to characterize the neuroanatomical dysfunction associated with dysregulated emotion after childbirth. Twenty postpartum women underwent fMRI in the presence of emotionally valenced stimuli. The observation of relative amygdala non-responsivity in subjects demonstrating greater depression symptomotology stands in contrast to imaging studies of MDD and provides insight into possible phenotypic differences of PPD.
KW - Amygdala
KW - Neuroimaging
KW - Postpartum depression
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=80051579452&partnerID=8YFLogxK
U2 - 10.1007/s00737-011-0226-2
DO - 10.1007/s00737-011-0226-2
M3 - Article
C2 - 21713456
AN - SCOPUS:80051579452
SN - 1434-1816
VL - 14
SP - 355
EP - 359
JO - Archives of Women's Mental Health
JF - Archives of Women's Mental Health
IS - 4
ER -