TY - JOUR
T1 - The Nebulin family
T2 - An actin support group
AU - Pappas, Christopher T.
AU - Bliss, Katherine T.
AU - Zieseniss, Anke
AU - Gregorio, Carol C.
N1 - Funding Information:
Christopher T. Pappas and Katherine T. Bliss contributed equally to this work. We would like to thank Samantha Whitman, Andrew Paek, Michael Dellinger and Henk Granzier for critical reading of this review. Because of the breadth of the subject matter in this review and space limitations, we were unable to discuss all the relevant references. This work was supported by an NIH grant (HL083146) to CCG, and an NIH HLB training grant (HL07249) to KTB.
PY - 2011/1
Y1 - 2011/1
N2 - Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues. For decades, nebulin has been thought to act as a molecular ruler, specifying the precise length of actin filaments in skeletal muscle. However, emerging evidence suggests that nebulin should not be viewed as a ruler but as an actin filament stabilizer required for length maintenance. Nebulin has also been implicated recently in an array of regulatory functions independent of its role in actin filament length regulation. In this review, we discuss the current evolutionary, biochemical, and functional data for the nebulin family of proteins - a family whose members, both large and small, function as cytoskeletal scaffolds and stabilizers.
AB - Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues. For decades, nebulin has been thought to act as a molecular ruler, specifying the precise length of actin filaments in skeletal muscle. However, emerging evidence suggests that nebulin should not be viewed as a ruler but as an actin filament stabilizer required for length maintenance. Nebulin has also been implicated recently in an array of regulatory functions independent of its role in actin filament length regulation. In this review, we discuss the current evolutionary, biochemical, and functional data for the nebulin family of proteins - a family whose members, both large and small, function as cytoskeletal scaffolds and stabilizers.
UR - http://www.scopus.com/inward/record.url?scp=78650556675&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2010.09.005
DO - 10.1016/j.tcb.2010.09.005
M3 - Review article
C2 - 20951588
AN - SCOPUS:78650556675
SN - 0962-8924
VL - 21
SP - 29
EP - 37
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -