The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses

Terrence M. Tumpey, Kristy J. Szretter, Neal Van Hoeven, Jacqueline M. Katz, Georg Kochs, Otto Haller, Adolfo García-Sastre, Peter Staeheli

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1-/- mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.

Original languageEnglish
Pages (from-to)10818-10821
Number of pages4
JournalJournal of Virology
Volume81
Issue number19
DOIs
StatePublished - Oct 2007

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