Abstract
Adaptive coevolution of mammals and bacteria has led to the establishment of complex commensal communities on mucosal surfaces. Despite having available a wealth of immune sensing and effector mechanisms capable of triggering inflammation, the intestinal mucosa establishes an intimate dialogue with microbes to generate a state of hyporesponsiveness against commensals and active readiness against pathogens. A key component of this homeostatic balance is immunoglobulin A, a noninflammatory antibody isotype produced by mucosal B cells through class switching. Here we discuss the function of immunoglobulin A and the mechanisms by which intestinal B cells undergo immunoglobulin A diversification and production to establish a symbiotic relationship with commensal bacteria.
| Original language | English |
|---|---|
| Title of host publication | Molecular Biology of B Cells |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 227-291 |
| Number of pages | 65 |
| ISBN (Electronic) | 9780123984906 |
| ISBN (Print) | 9780123979339 |
| DOIs | |
| State | Published - 15 Dec 2014 |
Keywords
- Activation-induced cytidine deaminase (AID)
- B cells
- Class switch recombination (CSR)
- Dendritic cells (DCs)
- Follicular dendritic cells (FDCs)
- Gut-associated lymphoid tissue (GALT)
- Immunoglobulin A (IgA)
- Innate lymphoid cells (ILCs)
- Lamina propria (LP)
- Mesenteric lymph nodes (MLNs)
- Peyer's patches (PPs)
- Somatic hypermutation (SHM)
- Stromal cells (SCs)
- T cell-dependent (TD)
- T cell-independent (TI)