@article{7d595f93b65c4d5baf83c7d920e806c4,
title = "The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer{\textquoteright}s disease",
abstract = "Alzheimer{\textquoteright}s disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and can neither provide clinically meaningful prediction of development of AD nor offer actionable mechanisms. This cohort study generated large-scale matched multi-Omics data in AD and control brains for exploring novel molecular underpinnings of AD. Specifically, we generated whole genome sequencing, whole exome sequencing, transcriptome sequencing and proteome profiling data from multiple regions of 364 postmortem control, mild cognitive impaired (MCI) and AD brains with rich clinical and pathophysiological data. All the data went through rigorous quality control. Both the raw and processed data are publicly available through the Synapse software platform.",
author = "Minghui Wang and Beckmann, {Noam D.} and Panos Roussos and Erming Wang and Xianxiao Zhou and Qian Wang and Chen Ming and Ryan Neff and Weiping Ma and Fullard, {John F.} and Hauberg, {Mads E.} and Jaroslav Bendl and Peters, {Mette A.} and Ben Logsdon and Pei Wang and Milind Mahajan and Mangravite, {Lara M.} and Dammer, {Eric B.} and Duong, {Duc M.} and Lah, {James J.} and Seyfried, {Nicholas T.} and Levey, {Allan I.} and Buxbaum, {Joseph D.} and Michelle Ehrlich and Sam Gandy and Pavel Katsel and Vahram Haroutunian and Eric Schadt and Bin Zhang",
note = "Funding Information: This work was supported by the grants R01AG046170, RF1AG054014, RF1AG057440 and R01AG057907 from the NIH/National Institute on Aging (NIA). R01AG046170 is a component of the AMP-AD Target Discovery and Preclinical Validation Project. Brain tissue collection and characterization was supported by NIH HHSN271201300031C. Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2018",
month = sep,
day = "11",
doi = "10.1038/sdata.2018.185",
language = "English",
volume = "5",
journal = "Scientific data",
issn = "2052-4463",
publisher = "Nature Publishing Group",
}