TY - JOUR
T1 - The molecular basis of reactive amyloidosis
AU - Yakar, Shoshana
AU - Livneh, Avi
AU - Kaplan, Batia
AU - Pras, Mordechai
PY - 1995/2
Y1 - 1995/2
N2 - Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH2-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.
AB - Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH2-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.
KW - Reactive amyloidosis
KW - amyloid protein A
KW - serum amyloid A
UR - http://www.scopus.com/inward/record.url?scp=0028838102&partnerID=8YFLogxK
U2 - 10.1016/S0049-0172(95)80035-2
DO - 10.1016/S0049-0172(95)80035-2
M3 - Article
C2 - 7740305
AN - SCOPUS:0028838102
SN - 0049-0172
VL - 24
SP - 255
EP - 261
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 4
ER -