The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

Matthew Nayor, Kemar J. Brown, Ramachandran S. Vasan

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.

Original languageEnglish
Pages (from-to)287-303
Number of pages17
JournalCirculation Research
Volume128
Issue number2
DOIs
StatePublished - 22 Jan 2021
Externally publishedYes

Keywords

  • cardiovascular disease
  • coronary artery disease
  • metabolome
  • proteomics

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