TY - JOUR
T1 - The molecular and genetic basis of colon cancer
AU - Robbins, David H.
AU - Itzkowitz, Steven H.
N1 - Funding Information:
This work was supported in part by grant no. CA81363 from the National Institutes of Health.
PY - 2002/11
Y1 - 2002/11
N2 - Remarkable progress has been accomplished in understanding the molecular basis of genetic colon cancer syndromes including FAP and HNPCC, and their variants; of sporadic colon cancer; and of the rare hamartomatous polyp syndromes. This molecular progress now has to be translated into clinical progress in molecular diagnosis, and in pharmacologic therapy for colonic polyps and cancers. It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer.
AB - Remarkable progress has been accomplished in understanding the molecular basis of genetic colon cancer syndromes including FAP and HNPCC, and their variants; of sporadic colon cancer; and of the rare hamartomatous polyp syndromes. This molecular progress now has to be translated into clinical progress in molecular diagnosis, and in pharmacologic therapy for colonic polyps and cancers. It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer.
UR - http://www.scopus.com/inward/record.url?scp=0036867742&partnerID=8YFLogxK
U2 - 10.1016/S0025-7125(02)00084-6
DO - 10.1016/S0025-7125(02)00084-6
M3 - Review article
C2 - 12510461
AN - SCOPUS:0036867742
SN - 0025-7125
VL - 86
SP - 1467
EP - 1495
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 6
ER -