The molecular and genetic basis of colon cancer

David H. Robbins, Steven H. Itzkowitz

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Remarkable progress has been accomplished in understanding the molecular basis of genetic colon cancer syndromes including FAP and HNPCC, and their variants; of sporadic colon cancer; and of the rare hamartomatous polyp syndromes. This molecular progress now has to be translated into clinical progress in molecular diagnosis, and in pharmacologic therapy for colonic polyps and cancers. It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer.

Original languageEnglish
Pages (from-to)1467-1495
Number of pages29
JournalMedical Clinics of North America
Issue number6
StatePublished - Nov 2002


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