Abstract
T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.
Original language | English |
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Pages (from-to) | 173-182 |
Number of pages | 10 |
Journal | Clinical and Applied Immunology Reviews |
Volume | 3 |
Issue number | 4-5 |
DOIs | |
State | Published - Jan 2003 |
Externally published | Yes |
Keywords
- Cross-presentation
- Cytolytic T cells
- Dentritic cells
- Helper T cells
- Immunotherapy