The mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond

Timothy C. Kenny; Giovanni Manfredi; Doris Germain

doi:10.3389/fonc.2017.00159

The mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond

Timothy C. Kenny, Giovanni Manfredi, Doris Germain

Research output: Contribution to journal › Short survey › peer-review

24 Scopus citations

Abstract

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR^mt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR^mt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR^mt in other diseases is also emerging and is therefore also briefly discussed.

Original language	English
Article number	159
Journal	Frontiers in Oncology
Volume	7
Issue number	JUL
DOIs	https://doi.org/10.3389/fonc.2017.00159
State	Published - 26 Jul 2017

Keywords

ALS
Cancer
Estrogen receptor
Mitochondria
Mitochondrial unfolded protein response
Sirtuin deacetylase

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10.3389/fonc.2017.00159

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title = "The mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond",

abstract = "Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.",

keywords = "ALS, Cancer, Estrogen receptor, Mitochondria, Mitochondrial unfolded protein response, Sirtuin deacetylase",

author = "Kenny, {Timothy C.} and Giovanni Manfredi and Doris Germain",

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AU - Kenny, Timothy C.

AU - Manfredi, Giovanni

AU - Germain, Doris

PY - 2017/7/26

Y1 - 2017/7/26

N2 - Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.

AB - Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.

KW - ALS

KW - Cancer

KW - Estrogen receptor

KW - Mitochondria

KW - Mitochondrial unfolded protein response

KW - Sirtuin deacetylase

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JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - JUL

M1 - 159

ER -

The mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond

Abstract

Keywords

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