@article{9ad9b9704c594623ab69b72eece28430,
title = "The mitochondrial multi-omic response to exercise training across rat tissues",
abstract = "Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta-hydroxysteroid dehydrogenase 10 (HSD17B10) elevated oxygen consumption, indicative of metabolic stress. We provide a multi-omic, multi-tissue, temporal atlas of the mitochondrial response to exercise training and identify candidates linked to mitochondrial dysfunction.",
keywords = "HSD17B10, acetylome, aerobic, exercise, metabolism, metabolomics, mitochondria, multi-omics, proteomics, transcriptomics",
author = "{the MoTrPAC Study Group} and David Amar and Gay, {Nicole R.} and David Jimenez-Morales and {Jean Beltran}, {Pierre M.} and Ramaker, {Megan E.} and Raja, {Archana Natarajan} and Bingqing Zhao and Yifei Sun and Shruti Marwaha and Gaul, {David A.} and Hershman, {Steven G.} and Alexis Ferrasse and Ashley Xia and Ian Lanza and Fern{\'a}ndez, {Facundo M.} and Montgomery, {Stephen B.} and Hevener, {Andrea L.} and Ashley, {Euan A.} and Walsh, {Martin J.} and Sparks, {Lauren M.} and Burant, {Charles F.} and Rector, {R. Scott} and John Thyfault and Wheeler, {Matthew T.} and Goodpaster, {Bret H.} and Coen, {Paul M.} and Simon Schenk and Bodine, {Sue C.} and Lindholm, {Malene E.} and Adkins, {Joshua N.} and Armenteros, {Jose Juan Almagro} and Amper, {Mary Anne S.} and Dam Bae and Marcas Bamman and Nasim Bararpour and Jerry Barnes and Bergman, {Bryan C.} and Bessesen, {Daniel H.} and Broskey, {Nicholas T.} and Buford, {Thomas W.} and Steven Carr and Chambers, {Toby L.} and Clarisa Chavez and Roxanne Chiu and Natalie Clark and Yongchao Ge and Nair, {Venugopalan D.} and Sealfon, {Stuart C.} and Smith, {Gregory R.} and Elena Zaslavsky",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2024",
month = jun,
day = "4",
doi = "10.1016/j.cmet.2023.12.021",
language = "English",
volume = "36",
pages = "1411--1429.e10",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}