The metabolism of intravenous [7α-3H]cholesterol [1-14C]palmitate in man

R. S. Rosenfeld, B. Zumoff, L. Hellman

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4 Scopus citations

Abstract

Synthetic [7α-3H]cholesterol [1-14C]palmitate was administered intravenously to two subjects in order to study the fate of cholesterol ester injected into the peripheral circulation. By 3 min over 80% of the injected cholesterol palmitate had disappeared from the plasma and by 10 h, the specific activity (3H) of free cholesterol was 3 to 5 times greater than the specific activity of cholesterol from the ester fraction. During this interval, the 14C:3H ratio rapidly declined and then leveled off at about 6% of the initial ratio in the injected cholesterol palmitate. These observations demonstrate the rapid removal of the injected ester followed by hydrolysis and reappearance of the cholesterol moiety in plasma both in free and esterified form. The efficiency of removal and hydrolysis of newly absorbed dietary sterol which enters the circulation largely as cholesterol ester may be of pertinence to the process of atherogenesis.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalAtherosclerosis
Volume13
Issue number1
DOIs
StatePublished - 1971
Externally publishedYes

Keywords

  • Cholesterol esters in man
  • Cholesterol metabolism in man
  • Esterification of cholesterol in man

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