@article{e540d57d4bdf4859b85c6ac61b2027c5,
title = "The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein",
abstract = "cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein.",
keywords = "CAMP, Metabolic sensor, Microdomain, Tumor suppressor, sAC",
author = "Lavoisier Ramos-Espiritu and Ana Diaz and Charlee Nardin and Saviola, \{Anthony J.\} and Fiona Shaw and Tamar Plitt and Xia Yang and Jedd Wolchok and Pirog, \{Edyta C.\} and Garrett Desman and Andrea Sboner and Tuo Zhang and Jenny Xiang and Taha Merghoub and Levin, \{Lonny R.\} and Jochen Buck and Zippin, \{Jonathan H.\}",
note = "Funding Information: L.R.E. is funded in part by GM107442 (L.R.L. and J.B.). C.N. is funded in part by Universit{\'e} de Franche Comt{\'e} Sciences M{\'e}dicales et Pharmaceutiques-Ann{\'e}e-Recherche 2013, Soci{\'e}t{\'e} Fran{\c c}aise de Dermatologie-AO bourse de soutien pour la formation {\`a} la recherche en dermatologie, and Coll{\`e}ge des Enseignants de Dermatologie En France-Bourse CEDEF d'aide {\`a} la mobilit{\'e}. F.S. is funded in part by the Melanoma Research Alliance Team Science Award and the American Skin Association. A.J.S. is supported in part by National Cancer Institute (NCI) Grant NIH T32 CA062948. J.W. and T.M. are funded in part by Swim Across America, Ludwig Cancer Research, and Annenberg-Hazen Foundation. J.H.Z is funded in part by a Melanoma Research Alliance Team Science Award, Clinique Clinical Scholars Award, and NCI (K08 CA 160657-01).",
year = "2016",
doi = "10.18632/oncotarget.10056",
language = "English",
volume = "7",
pages = "45597--45607",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "29",
}