The mental disabilities of metachromatic leukodystrophy: Implications concerning the differentiation of cortical, subcortical gray, and white matter dementias

Arnold E. Merriam, Angela M. Hegarty, Aaron Miller

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

There have been recent efforts to identify the distinguishing clinical features of cortical, subcortical white matter, and subcortical gray matter dementias. The case of a patient with dementia on the basis of metachromatic leukodystrophy, a well-characterized white matter disorder, is reported and discussed in the context of the purported differential features of these syndromes. It is concluded that white matter diseases can closely mimic subcortical gray matter diseases, even to the extent of exhibiting movement disorders classically seen in states primarily afflicting subcortical gray matter.

Original languageEnglish
Pages (from-to)217-225
Number of pages9
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Volume3
Issue number3
StatePublished - 1990
Externally publishedYes

Keywords

  • Cortical dementia
  • Metachromatic leukodystrophy
  • Movement disorders
  • Subcortical gray matter dementia
  • Subcortical white matter dementia

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