The mechanisms of vision loss associated with a cotton wool spot

Toco Y.P. Chui; Larry N. Thibos; Arthur Bradley; Stephen A. Burns

doi:10.1016/j.visres.2009.08.017

The mechanisms of vision loss associated with a cotton wool spot

Toco Y.P. Chui, Larry N. Thibos, Arthur Bradley, Stephen A. Burns

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.

Original language	English
Pages (from-to)	2826-2834
Number of pages	9
Journal	Vision Research
Volume	49
Issue number	23
DOIs	https://doi.org/10.1016/j.visres.2009.08.017
State	Published - 23 Nov 2009
Externally published	Yes

Keywords

Adaptive optics
Cotton wool spot
Optical coherence tomography
Retinal nerve fiber layer
Retinal sampling
Scanning laser ophthalmoscope

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10.1016/j.visres.2009.08.017

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title = "The mechanisms of vision loss associated with a cotton wool spot",

abstract = "We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.",

keywords = "Adaptive optics, Cotton wool spot, Optical coherence tomography, Retinal nerve fiber layer, Retinal sampling, Scanning laser ophthalmoscope",

author = "Chui, {Toco Y.P.} and Thibos, {Larry N.} and Arthur Bradley and Burns, {Stephen A.}",

note = "Funding Information: This work was supported by NIH Grant R01-EY05109 to LNT and NIH Grants R01-EY14375 and R01-EY04395 to SAB. We thank Dr. Victor E. Malinovsky and Dr. Hua Gao of the Indiana University School of Optometry for clinical consultations and Ms. Michelle Cornett from the Indiana University Community Eye Care Center for supplying the clinical data and fundus images. We also thank Irit Zakaim and Hongxin Song for assistance with data collection. Special thanks to Professor W.R. Levick of the Australian National University for his insights into the neurophysiological implications of retinal ischemia.",

year = "2009",

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doi = "10.1016/j.visres.2009.08.017",

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AU - Chui, Toco Y.P.

AU - Thibos, Larry N.

AU - Bradley, Arthur

AU - Burns, Stephen A.

N1 - Funding Information: This work was supported by NIH Grant R01-EY05109 to LNT and NIH Grants R01-EY14375 and R01-EY04395 to SAB. We thank Dr. Victor E. Malinovsky and Dr. Hua Gao of the Indiana University School of Optometry for clinical consultations and Ms. Michelle Cornett from the Indiana University Community Eye Care Center for supplying the clinical data and fundus images. We also thank Irit Zakaim and Hongxin Song for assistance with data collection. Special thanks to Professor W.R. Levick of the Australian National University for his insights into the neurophysiological implications of retinal ischemia.

PY - 2009/11/23

Y1 - 2009/11/23

N2 - We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.

AB - We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.

KW - Adaptive optics

KW - Cotton wool spot

KW - Optical coherence tomography

KW - Retinal nerve fiber layer

KW - Retinal sampling

KW - Scanning laser ophthalmoscope

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JO - Vision Research

JF - Vision Research

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The mechanisms of vision loss associated with a cotton wool spot

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Keywords

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