The mechanical properties of the lungs in experimental asthma in the guinea pig

Marvin Stein; Raul C. Schiavi; Perry Ottenberg; Charles Hamilton

doi:10.1016/0021-8707(61)90033-8

The mechanical properties of the lungs in experimental asthma in the guinea pig

Marvin Stein
, Raul C. Schiavi
, Perry Ottenberg
, Charles Hamilton

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

1. 1. A technique has been described which permits the quantitative measurement of the resistance to air flow and compliance in experimental asthma in the guinea pig. 2. 2. Animals exposed to histamine reacted uniformly with a significant increase in resistance and decrease in compliance. 3. 3. In contrast, there was a wide range of variation in the changes in resistance and compliance of the sensitized animals exposed to the antigen. The reactivity varied from no response to marked changes in the mechanics of breathing in lethal anaphylactic shock. 4. 4. The mechanics of breathing in experimental allergic asthma are similar to human bronchial asthma.

Original language	English
Pages (from-to)	8-16
Number of pages	9
Journal	Journal of Allergy and Clinical Immunology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0021-8707(61)90033-8
State	Published - 1961
Externally published	Yes

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title = "The mechanical properties of the lungs in experimental asthma in the guinea pig",

abstract = "1. 1. A technique has been described which permits the quantitative measurement of the resistance to air flow and compliance in experimental asthma in the guinea pig. 2. 2. Animals exposed to histamine reacted uniformly with a significant increase in resistance and decrease in compliance. 3. 3. In contrast, there was a wide range of variation in the changes in resistance and compliance of the sensitized animals exposed to the antigen. The reactivity varied from no response to marked changes in the mechanics of breathing in lethal anaphylactic shock. 4. 4. The mechanics of breathing in experimental allergic asthma are similar to human bronchial asthma.",

author = "Marvin Stein and Schiavi, \{Raul C.\} and Perry Ottenberg and Charles Hamilton",

note = "Funding Information: Presented in part at the Sixteenth *\%nnual Meeting Holly\textasciitilde{}\textasciitilde{}-ood-by-the-Sea, Florida, Jan. 13, 1960. This investigation was supported by grants from Infectious Diseases (E-1922) and from The National National Institutes of Health, IJ. S. Public Health Service, Received for publication May 16, 1960. *Fellow, Foundations Fund for Research",

year = "1961",

doi = "10.1016/0021-8707(61)90033-8",

language = "English",

volume = "32",

pages = "8--16",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0021-8707",

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T1 - The mechanical properties of the lungs in experimental asthma in the guinea pig

AU - Stein, Marvin

AU - Schiavi, Raul C.

AU - Ottenberg, Perry

AU - Hamilton, Charles

N1 - Funding Information: Presented in part at the Sixteenth *%nnual Meeting Holly~~-ood-by-the-Sea, Florida, Jan. 13, 1960. This investigation was supported by grants from Infectious Diseases (E-1922) and from The National National Institutes of Health, IJ. S. Public Health Service, Received for publication May 16, 1960. *Fellow, Foundations Fund for Research

PY - 1961

Y1 - 1961

N2 - 1. 1. A technique has been described which permits the quantitative measurement of the resistance to air flow and compliance in experimental asthma in the guinea pig. 2. 2. Animals exposed to histamine reacted uniformly with a significant increase in resistance and decrease in compliance. 3. 3. In contrast, there was a wide range of variation in the changes in resistance and compliance of the sensitized animals exposed to the antigen. The reactivity varied from no response to marked changes in the mechanics of breathing in lethal anaphylactic shock. 4. 4. The mechanics of breathing in experimental allergic asthma are similar to human bronchial asthma.

AB - 1. 1. A technique has been described which permits the quantitative measurement of the resistance to air flow and compliance in experimental asthma in the guinea pig. 2. 2. Animals exposed to histamine reacted uniformly with a significant increase in resistance and decrease in compliance. 3. 3. In contrast, there was a wide range of variation in the changes in resistance and compliance of the sensitized animals exposed to the antigen. The reactivity varied from no response to marked changes in the mechanics of breathing in lethal anaphylactic shock. 4. 4. The mechanics of breathing in experimental allergic asthma are similar to human bronchial asthma.

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U2 - 10.1016/0021-8707(61)90033-8

DO - 10.1016/0021-8707(61)90033-8

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AN - SCOPUS:1442336973

SN - 0021-8707

VL - 32

SP - 8

EP - 16

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

The mechanical properties of the lungs in experimental asthma in the guinea pig

Abstract

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