The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

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Abstract

Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context. Hence, Mdm2 is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.

Original languageEnglish
Pages (from-to)1580-1589
Number of pages10
JournalGenes and Development
Volume24
Issue number15
DOIs
StatePublished - 1 Aug 2010

Keywords

  • Mdm2
  • Oncogene
  • Tumor suppressor
  • Tumorigenesis
  • Ubiquitination
  • p53

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