TY - JOUR
T1 - The Maudsley Family study
T2 - Premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia
AU - Toulopoulou, Timothea
AU - Quraishi, Seema
AU - McDonald, Colm
AU - Murray, Robin M.
PY - 2006/2
Y1 - 2006/2
N2 - The distinction of psychosis into schizophrenia and bipolar disorder has been increasingly challenged with some evidence suggesting that the two conditions may have common etiologic and pathogenic mechanisms. We compared the premorbid and current intellectual function of bipolar patients from multiply affected families, and those of their first-degree relatives, with those of a similar series of schizophrenic subjects, as well as their relatives, and normal controls. Only schizophrenic subjects showed lower premorbid IQ, suggesting that they, but not the bipolar patients or either relative group, had suffered neurodevelopmental impairment. However, both groups of patients had comparably poor current general intellectual levels, implying that some common pathogenic process operates once illness has begun. The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods.
AB - The distinction of psychosis into schizophrenia and bipolar disorder has been increasingly challenged with some evidence suggesting that the two conditions may have common etiologic and pathogenic mechanisms. We compared the premorbid and current intellectual function of bipolar patients from multiply affected families, and those of their first-degree relatives, with those of a similar series of schizophrenic subjects, as well as their relatives, and normal controls. Only schizophrenic subjects showed lower premorbid IQ, suggesting that they, but not the bipolar patients or either relative group, had suffered neurodevelopmental impairment. However, both groups of patients had comparably poor current general intellectual levels, implying that some common pathogenic process operates once illness has begun. The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods.
UR - http://www.scopus.com/inward/record.url?scp=32844474158&partnerID=8YFLogxK
U2 - 10.1080/13803390500360513
DO - 10.1080/13803390500360513
M3 - Article
C2 - 16484096
AN - SCOPUS:32844474158
SN - 1380-3395
VL - 28
SP - 243
EP - 259
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 2
ER -